Event-related functional MRI: Past, present, and future

被引:388
作者
Rosen, BR
Buckner, RL
Dale, AM
机构
[1] Massachusetts Gen Hosp, Nucl Magnet Resonance Ctr, Charlestown, MA 02129 USA
[2] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA
[3] Washington Univ, Dept Psychol, St Louis, MO 63105 USA
[4] Washington Univ, Dept Radiol, St Louis, MO 63105 USA
[5] Washington Univ, Dept Anat & Neurobiol, St Louis, MO 63105 USA
关键词
single trial; echo planar imaging; functional neuroimaging; positron emission tomography; magnetoencephalography;
D O I
10.1073/pnas.95.3.773
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The past two decades have seen an enormous growth in the field of human brain mapping, Investigators have extensively exploited techniques such as positron emission tomography and MRI to map patterns of brain activity based on changes in cerebral hemodynamics. However, until recently, most studies have investigated equilibrium changes in blood flow measured over time periods upward of 1 min, The advent of high-speed MRI methods, capable of imaging the entire brain with a temporal resolution of a few seconds, allows for brain mapping based on more transient aspects of the hemodynamic response, Today it is now possible to map changes in cerebrovascular parameters essentially in real time, conferring the ability to observe changes in brain state that occur over time periods of seconds, Furthermore, because robust hemodynamic alterations are detectable after neuronal stimuli lasting only a few tens of milliseconds, a new class of task paradigms designed to measure regional responses to single sensory or cognitive events can now be studied, Such "event related" functional MRI should provide for fundamentally new ways to interrogate brain function, and allow for the direct comparison and ultimately integration of data acquired by using more traditional behavioral and electrophysiological methods.
引用
收藏
页码:773 / 780
页数:8
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