Connexins: Gaps in our knowledge of vascular function

被引:109
作者
Figueroa, XF [1 ]
Isakson, BE [1 ]
Duling, BR [1 ]
机构
[1] Univ Virginia, Dept Mol Physiol & Biol Phys, Cardiovasc Res Ctr, Charlottesville, VA 22908 USA
关键词
D O I
10.1152/physiol.00008.2004
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Gap junctions are common features in the vasculature, long thought to provide a pathway for cell-cell signaling. Emerging understanding of the gap-junctional proteins (connexins) and new tools for their investigation now offer the opportunity to explore the vital role that the gap junctions may play in cardiovascular homeostasis and pathophysiology.
引用
收藏
页码:277 / 284
页数:8
相关论文
共 60 条
[1]   Smooth muscle membrane potential modulates endothelium-dependent relaxation of rat basilar artery via myo-endothelial gap junctions [J].
Allen, T ;
Iftinca, M ;
Cole, WC ;
Plane, F .
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 545 (03) :975-986
[2]  
Bény JL, 1999, NEWS PHYSIOL SCI, V14, P68
[3]   AN ELECTRON-MICROSCOPIC STUDY OF SMOOTH-MUSCLE CELL DYE COUPLING IN THE PIG CORONARY-ARTERIES - ROLE OF GAP-JUNCTIONS [J].
BENY, JL ;
CONNAT, JL .
CIRCULATION RESEARCH, 1992, 70 (01) :49-55
[4]  
Beny JL, 1997, PFLUG ARCH EUR J PHY, V433, P364
[5]   Connexin mimetic peptides reversibly inhibit Ca2+ signaling through gap junctions in airway cells [J].
Boitano, S ;
Evans, WH .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 279 (04) :L623-L630
[6]   EDHF:: bringing the concepts together [J].
Busse, R ;
Edwards, G ;
Félétou, M ;
Fleming, I ;
Vanhoutte, PM ;
Weston, AH .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (08) :374-380
[7]   Connexin37, not Cx40 and Cx43, is induced in vascular smooth muscle cells during coronary arteriogenesis [J].
Cai, WJ ;
Koltai, S ;
Kocsis, E ;
Scholz, D ;
Schaper, W ;
Schaper, J .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (05) :957-967
[8]   Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery [J].
Chaytor, AT ;
Martin, PEM ;
Edwards, DH ;
Griffith, TM .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 280 (06) :H2441-H2450
[9]   Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries [J].
Chaytor, AT ;
Evens, WH ;
Griffith, TM .
JOURNAL OF PHYSIOLOGY-LONDON, 1998, 508 (02) :561-573
[10]   Impaired conduction of vasodilation along arterioles in connexin40-deficient mice [J].
de Wit, C ;
Roos, F ;
Bolz, SS ;
Kirchhoff, S ;
Krüger, O ;
Willecke, K ;
Pohl, U .
CIRCULATION RESEARCH, 2000, 86 (06) :649-655