ASIAN: a website for network inference

被引:9
作者
Aburatani, S
Goto, K
Saito, S
Fumoto, M
Imaizumi, A
Sugaya, N
Murakami, H
Sato, M
Toh, H
Horimoto, K
机构
[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Biostat,Minato Ku, Tokyo 1088639, Japan
[2] Infocom Corp, Biosci Grp, Chiyoda Ku, Tokyo 1010062, Japan
[3] Ajinomoto Co Inc, Adv Technol Dept, Fermentat & Biotechnol Labs, Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan
[4] Fujitsu Ltd, Comp Sci & Engn Ctr, Mihama Ku, Chiba 2618588, Japan
[5] Kyoto Univ, Inst Chem Res, Bioinformat Ctr, Kyoto 6110011, Japan
关键词
D O I
10.1093/bioinformatics/bth296
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We constructed a website for inferring a network by applying the graphical Gaussian model, from a large amount of data, including redundant information. The available tools on the website are based on a system, named ASIAN (Automatic System for Inferring A Network), in combination with the two methods in our previous papers, which were designed to analyze gene expression profiles on a genomic scale. One of the remarkable features of the website is its ability to infer a network, concomitant with hierarchical clustering and the following estimation of cluster boundaries.
引用
收藏
页码:2853 / 2856
页数:4
相关论文
共 13 条
[1]   Deduction of a gene regulatory relationship framework from gene expression data by the application of graphical Gaussian modeling [J].
Aburatani, S ;
Kuhara, S ;
Toh, H ;
Horimoto, K .
SIGNAL PROCESSING, 2003, 83 (04) :777-788
[2]  
Anderberg M.R., 1973, Probability and Mathematical Statistics
[3]  
[Anonymous], 2003, P 3 INT C DATA MININ
[4]  
[Anonymous], 1998, REGRESSION ANAL
[5]   COVARIANCE SELECTION [J].
DEMPSTER, AP .
BIOMETRICS, 1972, 28 (01) :157-&
[6]   Cluster analysis and display of genome-wide expression patterns [J].
Eisen, MB ;
Spellman, PT ;
Brown, PO ;
Botstein, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868
[7]  
GORDON AD, 1981, CLASSIFICATION
[8]   Statistical estimation of cluster boundaries in gene expressions profile data [J].
Horimoto, K ;
Toh, H .
BIOINFORMATICS, 2001, 17 (12) :1143-1151
[9]   Diverse and specific gene expression responses to stresses in cultured human cells [J].
Murray, JI ;
Whitfield, ML ;
Trinklein, ND ;
Myers, RM ;
Brown, PO ;
Botstein, D .
MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (05) :2361-2374
[10]   System for automatically inferring a genetic network from expression profiles [J].
Toh, H ;
Horimoto, K .
JOURNAL OF BIOLOGICAL PHYSICS, 2002, 28 (03) :449-464