Pathways mediating VEGF-independent tumor angiogenesis

被引：233

作者：

Ferrara, Napoleone ^{[1
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 01期

关键词：

Angiogenesis; VEGF; Bv8; Myeloid cells; Fibroblasts; ENDOTHELIAL-GROWTH-FACTOR; RECEPTOR TYROSINE KINASE; ANTI-VEGF; BLOOD-VESSELS; IN-VIVO; STROMAL FIBROBLASTS; PROLONGS SURVIVAL; SUPPRESSOR-CELLS; PROGENITOR CELLS; INNATE IMMUNITY;

D O I：

10.1016/j.cytogfr.2009.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

FDA approval of several inhibitors of the VEGF pathway has enabled significant advances in the therapy of cancer and neovascular age-related macular degeneration. However, similar to other therapies, inherent/acquired resistance to anti-angiogenic drugs may occur in patients, leading to disease progression. So far the lack of predictive biomarkers has precluded identification of patients most likely to respond to such treatments. Recent suggest that both tumor and non-tumor (stromal) cell types are involved in the reduced responsiveness to the treatments. The present review examines the role of tumor- as well as stromal cell-derived pathways involved in tumor growth and in refractoriness to anti-VEGF therapies. (C) 2009 Elsevier Ltd. All rights reserved.

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页码：21 / 26

页数：6

相关论文

共 135 条

[1] VASCULAR REACTIONS OF NORMAL AND MALIGNANT TISSUES INVIVO .1. VASCULAR REACTIONS OF MICE TO WOUNDS AND TO NORMAL AND NEOPLASTIC TRANSPLANTS [J].

ALGIRE, GH ;

CHALKLEY, HW .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1945, 6 (01) :73-85

[2] Lymphangiogenesis in development and human disease [J].

Alitalo, K ;

Tammela, T ;

Petrova, TV .

NATURE, 2005, 438 (7070) :946-953

[3] Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype [J].

Almog, Nava ;

Ma, Lili ;

Raychowdhury, Raktima ;

Schwager, Christian ;

Erber, Ralf ;

Short, Sarah ;

Hlatky, Lynn ;

Vajkoczy, Peter ;

Huber, Peter E. ;

Folkman, Judah ;

Abdollahi, Amir .

CANCER RESEARCH, 2009, 69 (03) :836-844

[4] Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts [J].

Anderberg, Charlotte ;

Li, Hong ;

Fredriksson, Linda ;

Andrae, Johanna ;

Betsholtz, Christer ;

Li, Xuri ;

Eriksson, Ulf ;

Pietras, Kristian .

CANCER RESEARCH, 2009, 69 (01) :369-378

[5]

[Anonymous], J CLIN ONCOL S

[6] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[7] Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors [J].

Baluk, P ;

Morikawa, S ;

Haskell, A ;

Mancuso, M ;

McDonald, DM .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (05) :1801-1815

[8] AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J].

Batchelor, Tracy T. ;

Sorensen, A. Gregory ;

di Tomaso, Emmanuelle ;

Zhang, Wei-Ting ;

Duda, Dan G. ;

Cohen, Kenneth S. ;

Kozak, Kevin R. ;

Cahill, Daniel P. ;

Chen, Poe-Jou ;

Zhu, Mingwang ;

Ancukiewicz, Marek ;

Mrugala, Maciej M. ;

Plotkin, Scott ;

Drappatz, Jan ;

Louis, David N. ;

Ivy, Percy ;

Scadden, David T. ;

Benner, Thomas ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Jain, Rakesh K. .

CANCER CELL, 2007, 11 (01) :83-95

[9] The FGF family: biology, pathophysiology and therapy [J].

Beenken, Andrew ;

Mohammadi, Moosa .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (03) :235-253

[10] Innate immunity - Innate pathways that control acquired immunity [J].

Bendelac, A ;

Fearon, DT .

CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (01) :1-3

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