Fatty acid amide hydrolase substrate specificity

被引：93

作者：

Boger, DL

Fecik, RA

Patterson, JE

Miyauchi, H

Patricelli, MP

Cravatt, BF

机构：

[1] Scripps Res Inst, Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(00)00528-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2613 / 2616

页数：4

共 31 条

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