Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression

被引：61

作者：

Erez-Roman, Racheli ^{[1
]}

Pienik, Reut ^{[1
]}

Futerman, Anthony H. ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 391卷 / 01期

关键词：

Ceramide; Sphingolipid; Breast cancer; Real time PCR; LONGEVITY ASSURANCE GENE-1; SQUAMOUS-CELL CARCINOMAS; HUMAN HEAD; (DIHYDRO)CERAMIDE SYNTHASE; SPHINGOLIPID METABOLISM; SUBSTRATE-SPECIFICITY; FAMILY-MEMBERS; C-18-CERAMIDE; PATHOGENESIS; 1-PHOSPHATE;

D O I：

10.1016/j.bbrc.2009.11.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intervention in the ceramide metabolic pathway is emerging as a novel means to regulate cancer and to modify the activity of chemotherapeutic drugs We now Study mRNA expression levels of the six ceramide synthase (CerS) genes in breast cancer tissue CerS2 and CerS6 mRNA was significantly elevated in breast cancer tissue compared to paired normal tissue, with approximately half of the individuals showing elevated CerS2 and CerS6 mRNA. A significant correlation was found between CerS2 and CerS6 expression, and between CerS4 and CerS2/CerS6 expression Moreover, patients that expressed higher CerS2 or 4 mRNA levels tended to show no changes in sphingosine kinase 1 levels, and likewise patients that expressed no change in CerS2 or CerS4 mRNA levels tended to express higher levels of sphingosine kinase 1 Together these results Suggest an important role for the CerS genes in breast cancer etiology or diagnosis (c) 2009 Elsevier Inc All rights reserved

引用

页码：219 / 223

页数：5

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