A cohort study of the effect of alcohol consumption and obesity on serum liver enzyme levels

被引：30

作者：

Shen, Zhe ^{[1
]}

Li, Youming ^{[1
]}

Yu, Chaohui ^{[1
]}

Shen, Yi ^{[3
]}

Xu, Lei ^{[1
]}

Xu, Chengfu ^{[1
]}

Xu, Genyun ^{[2
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Clin Lab, Hangzhou 310003, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Dept Stat, Hangzhou 310003, Zhejiang, Peoples R China

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2010年 / 22卷 / 07期

关键词：

cohort study; epidemiology; ethanol; incidence; liver enzymes; obesity; FATTY LIVER; RISK-FACTORS; ALANINE AMINOTRANSFERASE; GENERAL-POPULATION; METABOLIC SYNDROME; ADULT-POPULATION; FOLLOW-UP; DISEASE; PREVALENCE; DIAGNOSIS;

D O I：

10.1097/MEG.0b013e3283328b86

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective To conduct a cohort study of the effect of alcohol and obesity on liver enzymes in China. Methods To study 500 individuals of liver enzymes normality randomly in the 1999-year epidemiological survey, and liver enzyme levels (461 complete data) in 2006. Results Logistic-regression analysis showed a daily alcohol intake of at least 40 g, duration of drinking at least 10 years, and obesity, which were closely related to abnormality in liver enzyme levels; the relative risk (95% confidence interval) was 2.014 (1.108-3.662), 2.085 (1.106-3.928), and 1.772 (1.140-2.754), respectively (all P < 0.05). According to the value of daily alcohol intake/duration of drinking and body mass index (BMI) to categorize, seven-year cumulative incidence of liver enzymes levels abnormality for the daily alcohol intake at least 40 g and obesity group or the duration of drinking at least 10 years and obesity group was the highest, 51.47 and 47.12%, respectively. No significant dose-response relationship was found between daily alcohol intake/duration of drinking and liver enzyme level abnormalities. Conclusion The risk of alcohol consumption and obesity-inducing liver injury together is far greater than the risk of a single factor inducing liver injury. An alcoholic threshold effect may be more important than a dose-response effect on liver enzyme levels. Eur J Gastroenterol Hepatol 22:820-825 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：820 / 825

页数：6

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