Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity

被引：22

作者：

Blanca, G

Baldanti, F

Paolucci, S

Skoblov, AY

Victorova, L

Hübscher, U

Gerna, G

Spadari, S

Maga, G

机构：

[1] CNR, IGM, I-27100 Pavia, Italy

[2] Policlin San Matteo, Serv Virol, Ist Ric & Cura Carattere Sci, I-27100 Pavia, Italy

[3] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 117984, Russia

[4] Univ Zurich Irchel, Inst Vet Biochem & Mol Biol, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2003年 / 278卷 / 18期

关键词：

D O I：

10.1074/jbc.C300022200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recombinant HIV-1 reverse transcriptase (RT) carrying non-nucleoside inhibitors (NNRTIs) resistance mutation at codon 181 showed reduced incorporation and high efficiency of phosphorolytic removal of stavudine, a nucleoside RT inhibitor. These results reveal a new mechanism for cross-resistance between different classes of HIV-1 RT inhibitors.

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收藏

页码：15469 / 15472

页数：4

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