Minireview:: Targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton

被引：473

作者：

Baron, Roland

Rawadi, Georges

机构：

[1] Yale Univ, Sch Med, New Haven, CT 06520 USA

[2] Galapagos, F-93230 Romainville, France

来源：

ENDOCRINOLOGY | 2007年 / 148卷 / 06期

关键词：

RECEPTOR-RELATED PROTEIN-5; LDL-RECEPTOR-RELATED-PROTEIN-5; LRP5; GENE; WNT SIGNALING PATHWAY; VAN-BUCHEM-DISEASE; OSTEOBLAST DIFFERENTIATION; CLEIDOCRANIAL DYSPLASIA; MINERAL DENSITY; BETA-CATENIN; OSTEOCLAST DIFFERENTIATION; DICKKOPF PROTEINS;

D O I：

10.1210/en.2007-0270

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recent identification of a link between bone mass in humans and gain- or loss-of-function mutations in the Wnt coreceptor low-density lipoprotein receptor-related protein 5 (osteoporosis pseudoglioma syndrome, high bone mass trait) or in the Wnt antagonist sclerostin (sclerosteosis, van Buchem syndrome) has called the attention of academic and industry scientists and clinicians to the importance of this signaling pathway in skeletal biology and disease. Multiple genetic and pharmacological manipulations of Wnt signaling in mice have since then confirmed the central role of this pathway in regulating bone formation.

引用

页码：2635 / 2643

页数：9

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