Microbial isoprenoid biosynthesis and human γδ T cell activation

被引：249

作者：

Eberl, M ^{[1
]}

Hintz, M ^{[1
]}

Reichenberg, A ^{[1
]}

Kollas, AK ^{[1
]}

Wiesner, J ^{[1
]}

Jomaa, H ^{[1
]}

机构：

[1] Univ Giessen, Inst Biochem, D-35392 Giessen, Germany

来源：

FEBS LETTERS | 2003年 / 544卷 / 1-3期

关键词：

GcpE; LytB; DOXP; MEP; HMB-PP; IPP;

D O I：

10.1016/S0014-5793(03)00483-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human Vgamma9/Vdelta2 T cells play a crucial role in the immune response to microbial pathogens, yet their unconventional reactivity towards non-peptide antigens has been enigmatic until recently. The break-through in identification of the specific activator was only possible due to recent success in a seemingly remote field: the elucidation of the reaction steps of the newly discovered 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway of isoprenoid biosynthesis that is utilised by many pathogenic bacteria. Unexpectedly, the intermediate of the MEP pathway, (E)-4-hydroxy-3-methyl-but-2-enyl-pyro-phosphate) (HMB-PP), turned out to be by far the most potent Vgamma9/Vdelta2 T cell activator known, with an EC50 of 0.1 nM. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

收藏

页码：4 / 10

页数：7

相关论文

共 66 条

[1] Biosynthesis of terpenes:: Studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase [J].

Adam, P ;

Hecht, S ;

Eisenreich, WG ;

Kaiser, J ;

Gräwert, T ;

Arigoni, D ;

Bacher, A ;

Rohdich, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (19) :12108-12113

[2] LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis [J].

Altincicek, B ;

Duin, EC ;

Reichenberg, A ;

Hedderich, R ;

Kollas, AK ;

Hintz, M ;

Wagner, S ;

Wiesner, J ;

Beck, E ;

Jomaa, H .

FEBS LETTERS, 2002, 532 (03) :437-440

[3] Cutting edge:: Human γδ T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis [J].

Altincicek, B ;

Moll, J ;

Campos, N ;

Foerster, G ;

Beck, E ;

Hoeffler, JF ;

Grosdemange-Billiard, C ;

Rodríguez-Concepción, M ;

Rohmer, M ;

Boronat, A ;

Eberl, M ;

Jomaa, H .

JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :3655-3658

[4] LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli [J].

Altincicek, B ;

Kollas, AK ;

Eberl, M ;

Wiesner, J ;

Sanderbrand, S ;

Hintz, M ;

Beck, E ;

Jomma, H .

FEBS LETTERS, 2001, 499 (1-2) :37-40

[5] GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli [J].

Altincicek, B ;

Kollas, AK ;

Sanderbrand, S ;

Wiesner, J ;

Hintz, M ;

Beck, E ;

Jomaa, H .

JOURNAL OF BACTERIOLOGY, 2001, 183 (08) :2411-2416

[6] Biosynthesis of terpenes.: Preparation of (E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate, an intermediate of the deoxyxylulose phosphate pathway [J].

Amslinger, S ;

Kis, K ;

Hecht, S ;

Adam, P ;

Rohdich, F ;

Arigoni, D ;

Bacher, A ;

Eisenreich, W .

JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (13) :4590-4594

[7] Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement [J].

Arigoni, D ;

Sagner, S ;

Latzel, C ;

Eisenreich, W ;

Bacher, A ;

Zenk, MH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10600-10605

[8] BIOSYNTHESIS OF MONOTERPENES [J].

BANTHORPE, DV ;

CHARLWOOD, BV ;

FRANCIS, MJO .

CHEMICAL REVIEWS, 1972, 72 (02) :115-+

[9] 3-formyl-1-butyl pyrophosphate A novel mycobacterial metabolite-activating human γδ T cells [J].

Belman, C ;

Espinosa, E ;

Poupot, R ;

Peyrat, MA ;

Guiraud, M ;

Poquet, Y ;

Bonneville, M ;

Fournié, JJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) :32079-32084

[10]

BROERS STJ, 1994, THESIS ETH ZURICH

← 1 2 3 4 5 6 7 →