Advances in the universal NMR database approach.: 2′-substituted taxanes as probes for an improved protocol of diastereomeric differentiation

被引：5

作者：

Dambruoso, P

Bassarello, C

Bifulco, G

Appendino, G

Battaglia, A

Fontana, G

Gomez-Paloma, L

机构：

[1] Univ Piemonte Orientale, Fac Farm, DISCAFF, I-28100 Novara, Italy

[2] Univ Salerno, Fac Farm, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

[3] CNR, ISOF, Area Ric Bologna, I-40129 Bologna, Italy

[4] Indena SPA, I-20139 Milan, Italy

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 06期

关键词：

D O I：

10.1021/ol047600d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The configuration of the alpha-substituted alpha-hydroxy-beta-aminoester moiety in a series of 2'-substituted taxanes was analyzed according to the recently proposed Universal NMR Database (UDB) approach. A critical analysis of the results showed that modifications regarding chemical shift adjustment (so as to render the shifts virtually connectivity independent) were necessary to get consistent stereoassignments in this set of compounds. On this basis, a modified UDB-based strategy, especially tailored to the configurational assignment of densely substituted diastereomeric fragments, is proposed.

引用

页码：983 / 986

页数：4

共 18 条

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