Ebola virus ecology:: a continuing mystery

被引:43
作者
Feldmann, H [1 ]
Wahl-Jensen, V
Jones, SM
Ströher, U
机构
[1] Hlth Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada
[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0W3, Canada
[3] Univ Manitoba, Dept Immunol, Winnipeg, MB R3E 0W3, Canada
关键词
D O I
10.1016/j.tim.2004.08.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Marburg and Ebola viruses emerged approximately three decades ago, but the reservoir(s) of these zoonotic pathogens and the routes of primary transmission to human and nonhuman primates remains a mystery. Recent outbreaks have been associated with multiple introductions into the population, indicating the circulation of distinct strains that have evolved in reservoir species that occupy different ecological niches. Identification of the viral reservoir(s) is a research priority, with a high impact on public health and prevention.
引用
收藏
页码:433 / 437
页数:5
相关论文
共 25 条
  • [1] Arata A., 1977, EBOLA VIRUS HAEMORRH, P191
  • [2] Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo
    Bausch, DG
    Borchert, M
    Grein, T
    Roth, C
    Swanepoel, R
    Libande, ML
    Talarmin, A
    Bertherat, E
    Muyembe-Tamfum, JJ
    Tugume, B
    Colebunders, R
    Kondé, KM
    Pirard, P
    Olinda, LL
    Rodier, GR
    Campbell, P
    Tomori, O
    Ksiazek, TG
    Rollin, PE
    [J]. EMERGING INFECTIOUS DISEASES, 2003, 9 (12) : 1531 - 1537
  • [3] A search for Ebola virus in animals in the Democratic Republic of the Congo and Cameroon: Ecologic, virologic, and serologic surveys, 1979-1980
    Breman, JG
    Johnson, KM
    van der Groen, G
    Robbins, CB
    Szczeniowski, MV
    Ruti, K
    Webb, PA
    Meier, F
    Heymann, DL
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1999, 179 : S139 - S147
  • [4] Ebola virus: from discovery to vaccine
    Feldmann, H
    Jones, S
    Klenk, HD
    Schnittler, HJ
    [J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (08) : 677 - 685
  • [5] Formenty P, 2003, Med Trop (Mars), V63, P291
  • [6] Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses
    Garbutt, M
    Liebscher, R
    Wahl-Jensen, V
    Jones, S
    Möller, P
    Wagner, R
    Volchkov, V
    Klenk, HD
    Feldmann, H
    Ströher, U
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (10) : 5458 - 5465
  • [7] Geisbert TW, 2002, EMERG INFECT DIS, V8, P503
  • [8] Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates
    Hevey, M
    Negley, D
    Pushko, P
    Smith, J
    Schmaljohn, A
    [J]. VIROLOGY, 1998, 251 (01) : 28 - 37
  • [9] Johnson ED, 1996, ARCH VIROL, P101
  • [10] Komar N, 2001, ANN NY ACAD SCI, V951, P58