Real-time photoacoustic tomography of cortical hemodynamics in small animals

被引：83

作者：

Li, Changhui ^{[1
]}

Aguirre, Andres ^{[2
]}

Gamelin, John ^{[2
]}

Maurudis, Anastasios ^{[2
]}

Zhu, Quing ^{[2
]}

Wang, Lihong V. ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, Opt Imaging Lab, St Louis, MO 63130 USA

[2] Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2010年 / 15卷 / 01期

基金：

美国国家卫生研究院;

关键词：

photoacoustic tomography; real time; noninvasive; BIOMEDICINE;

D O I：

10.1117/1.3302807

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3302807]

引用

页数：3

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