Lipoatrophy revisited

被引：155

作者：

Reitman, ML ^{[1
]}

Arioglu, E ^{[1
]}

Gavrilova, O ^{[1
]}

Taylor, SI ^{[1
]}

机构：

[1] NIDDKD, Diabet Branch, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 10期

关键词：

D O I：

10.1016/S1043-2760(00)00309-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The lipoatrophy syndromes are a heterogeneous group of syndromes characterized by a paucity of adipose tissue. Severe lipoatrophy is associated with insulin-resistant diabetes mellitus (DM). The loss of adipose tissue can have a genetic, immune, or infectious/drug-associated etiology. Causative mutations have been identified in patients for one form of partial lipoatrophy - Dunnigan-type familial partial lipodystrophy. Experiments using lipoatrophic mice demonstrate that the diabetes results from the lack of fat and that leptin deficiency is a contributing factor Thiazolidinedione therapy improves metabolic control in lipoatrophic patients; the efficacy of leptin treatment is currently being investigated.

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页码：410 / 416

页数：7

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