A new face of the Rhesus antigen

被引:27
作者
Heitman, J [1 ]
Agre, P
机构
[1] Duke Univ, Med Ctr, Dept Genet, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC USA
[3] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
关键词
D O I
10.1038/81532
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The Mep ammonium transporters of Saccharomyces cerevisiae share amino acid sequence identity with the Rh blood group antigen proteins. A new study shows that the Rhg glycoproteins transport ammonium when heterologously expressed in mep mutant yeast cells, indicating a role for the Rh antigen complex.
引用
收藏
页码:258 / 259
页数:2
相关论文
共 17 条
  • [1] The Rh blood group system: a review
    Avent, ND
    Reid, ME
    [J]. BLOOD, 2000, 95 (02) : 375 - 387
  • [2] METHYLAMINE-AMMONIA UPTAKE SYSTEMS IN SACCHAROMYCES-CEREVISIAE - MULTIPLICITY AND REGULATION
    DUBOIS, E
    GRENSON, M
    [J]. MOLECULAR & GENERAL GENETICS, 1979, 175 (01): : 67 - 76
  • [3] AMMONIUM TRANSPORT IN THE KIDNEY
    KNEPPER, MA
    PACKER, R
    GOOD, DW
    [J]. PHYSIOLOGICAL REVIEWS, 1989, 69 (01) : 179 - 249
  • [4] LANDSTEINER KARL, 1940, PROC SOC EXP BIOL AND MED, V43, P223
  • [5] Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis
    Liu, Z
    Chen, Y
    Mo, R
    Hui, CC
    Cheng, JF
    Mohandas, N
    Huang, CH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) : 25641 - 25651
  • [6] LIU Z, IN PRESS J BIOL CHEM
  • [7] The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae
    Lorenz, MC
    Heitman, J
    [J]. EMBO JOURNAL, 1998, 17 (05) : 1236 - 1247
  • [8] Cross-talk between ammonium transporters in yeast and interference by the soybean SAT1 protein
    Marini, AM
    Springael, JY
    Frommer, WB
    André, B
    [J]. MOLECULAR MICROBIOLOGY, 2000, 35 (02) : 378 - 385
  • [9] CLONING AND EXPRESSION OF THE MEP1 GENE ENCODING AN AMMONIUM TRANSPORTER IN SACCHAROMYCES-CEREVISIAE
    MARINI, AM
    VISSERS, S
    URRESTARAZU, A
    ANDRE, B
    [J]. EMBO JOURNAL, 1994, 13 (15) : 3456 - 3463
  • [10] The Rh (rhesus) blood group polypeptides are related to NH4+ transporters
    Marini, AM
    Urrestarazu, A
    Beauwens, R
    André, B
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (12) : 460 - 461