Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family

被引：72

作者：

Pushkin, A ^{[1
]}

Abuladze, N ^{[1
]}

Newman, D ^{[1
]}

Lee, I ^{[1
]}

Xu, GP ^{[1
]}

Kurtz, I ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Div Nephrol, Los Angeles, CA 90095 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2000年 / 1493卷 / 1-2期

关键词：

bicarbonate; sodium; transport; pH;

D O I：

10.1016/S0167-4781(00)00149-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the cloning, characterization and chromosomal assignment of a new member of the sodium bicarbonate cotransporter (NBC) family, NBC4, from human heart. NBC4 maps to chromosome 2p13 and is a new candidate gene for Alstrom syndrome. NBC4 encodes a 1074-residue polypeptide with 12 putative membrane-spanning domains. Unlike other members of the NBC family, NBC4 has a unique giycine-rich region (amino acids 438-485). In addition, NBC4 lacks the lysine-rich C-terminus ofNBC1 with which it is most homologous. The first of two putative stilbene binding motifs (K(M/L)(X)K) is lacking in NBC4 (amino acids 655-658). The similar to 6 kb NBC4 transcript is moderately expressed in heart, with the highest expression in liver, testes and spleen. O 2000 Elsevier Science B.V. All rights reserved.

引用

页码：215 / 218

页数：4

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