Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

被引：14

作者：

Phillips, JM ^{[1
]}

Latimer, MP ^{[1
]}

Gupta, S ^{[1
]}

Winn, P ^{[1
]}

Brown, VJ ^{[1
]}

机构：

[1] Univ St Andrews, Sch Psychol, St Andrews KY16 9JU, Fife, Scotland

来源：

BEHAVIOURAL BRAIN RESEARCH | 1998年 / 90卷 / 01期

基金：

英国惠康基金;

关键词：

basal ganglia; Parkinson's disease; sensorimotor asymmetry; subthalamic nucleus; rat;

D O I：

10.1016/S0166-4328(97)00080-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion. (C) 1998 Elsevier Science B.V.

引用

页码：73 / 77

页数：5

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