Increased hypothalamic neuropeptide Y concentration or hyperphagia in streptozotocin-diabetic rats are not mediated by glucocorticoids

被引：9

作者：

Dryden, S ^{[1
]}

Burns, SJ ^{[1
]}

Frankish, HM ^{[1
]}

Williams, G ^{[1
]}

机构：

[1] Univ Liverpool, Dept Med, Diabet & Endocrinol Res Unit, Liverpool L69 3GA, Merseyside, England

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 340卷 / 2-3期

基金：

英国惠康基金;

关键词：

diabetes; hypothalamus; neuropeptide Y; RU486;

D O I：

10.1016/S0014-2999(97)01410-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypothalamic neuropeptide Y containing neurones are overactive and may mediate hyperphagia in insulin-deficient diabetic rats, but the factors stimulating them remain uncertain. To determine the possible role of glucocorticoids, we investigated the effects of the glucocorticoid receptor blocker mifepristone (RU486) on food intake and regional hypothalamic neuropeptide Y concentrations in streptozotocin-diabetic rats. RU486 (30 mg/kg) or corn oil vehicle control was given orally for 3 weeks to diabetic rats. Food intake and neuropeptide Y levels in the hypothalamic arcuate and paraventricular nuclei were increased in untreated diabetic rat groups (P < 0.01), and though RU486 did increase plasma corticosterone levels (P < 0.01) it did not have any effect on either feeding or neuropeptide Y levels (P = NS). These negative findings suggest that glucocorticoids may not be responsible for increasing hypothalamic neuropeptide Y or for hyperphagia in insulin-deficient diabetes. (C) 1997 Elsevier Science B.V.

引用

页码：221 / 225

页数：5

共 30 条

[1] HYPOTHALAMIC NEUROPEPTIDE-Y, ITS GENE-EXPRESSION AND RECEPTOR ACTIVITY - RELATION TO CIRCULATING CORTICOSTERONE IN ADRENALECTOMIZED RATS [J].

AKABAYASHI, A ;

WATANABE, Y ;

WAHLESTEDT, C ;

MCEWEN, BS ;

PAEZ, X ;

LEIBOWITZ, SF .

BRAIN RESEARCH, 1994, 665 (02) :201-212

[2] RAPID AND LOCALIZED ALTERATIONS OF NEUROPEPTIDE-Y IN DISCRETE HYPOTHALAMIC NUCLEI WITH FEEDING STATUS [J].

BECK, B ;

JHANWARUNIYAL, M ;

BURLET, A ;

CHAPLEURCHATEAU, M ;

LEIBOWITZ, SF ;

BURLET, C .

BRAIN RESEARCH, 1990, 528 (02) :245-249

[3] THE ANATOMY OF NEUROPEPTIDE-Y-CONTAINING NEURONS IN RAT-BRAIN [J].

CHRONWALL, BM ;

DIMAGGIO, DA ;

MASSARI, VJ ;

PICKEL, VM ;

RUGGIERO, DA ;

ODONOHUE, TL .

NEUROSCIENCE, 1985, 15 (04) :1159-1181

[4] DEXAMETHASONE TREATMENT INCREASES NEUROPEPTIDE-Y LEVELS IN RAT HYPOTHALAMIC NEURONS [J].

CORDER, R ;

PRALONG, F ;

TURNILL, D ;

SAUDAN, P ;

MULLER, AF ;

GAILLARD, RC .

LIFE SCIENCES, 1988, 43 (23) :1879-1886

[5] NEUROPEPTIDE-Y AND ENERGY-BALANCE - ONE-WAY AHEAD FOR THE TREATMENT OF OBESITY [J].

DRYDEN, S ;

FRANKISH, H ;

WANG, Q ;

WILLIAMS, G .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1994, 24 (05) :293-308

[6] INCREASED NEUROPEPTIDE-Y SECRETION IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS OF OBESE (FA/FA) ZUCKER RATS [J].

DRYDEN, S ;

PICKAVANCE, L ;

FRANKISH, HM ;

WILLIAMS, G .

BRAIN RESEARCH, 1995, 690 (02) :185-188

[7]

DRYDEN S, 1997, CURR OPIN ENDOCRINOL, V4, P124

[8] NEUROPEPTIDE-Y RECEPTOR NUMBERS ARE REDUCED IN THE HYPOTHALAMUS OF STREPTOZOTOCIN-DIABETIC AND FOOD-DEPRIVED RATS - FURTHER EVIDENCE OF INCREASED ACTIVITY OF HYPOTHALAMIC NPY-CONTAINING PATHWAYS [J].

FRANKISH, HM ;

MCCARTHY, HD ;

DRYDEN, S ;

KILPATRICK, A ;

WILLIAMS, G .

PEPTIDES, 1993, 14 (05) :941-948

[9] NEUROPEPTIDE-Y, THE HYPOTHALAMUS, AND DIABETES - INSIGHTS INTO THE CENTRAL CONTROL OF METABOLISM [J].

FRANKISH, HM ;

DRYDEN, S ;

HOPKINS, D ;

WANG, Q ;

WILLIAMS, G .

PEPTIDES, 1995, 16 (04) :757-771

[10] NEUROPEPTIDE Y ADMINISTRATION ACUTELY INCREASES HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR IMMUNOREACTIVITY - LACK OF EFFECT IN OTHER RAT-BRAIN REGIONS [J].

HAAS, DA ;

GEORGE, SR .

LIFE SCIENCES, 1987, 41 (25) :2725-2731

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