Ferritins, iron uptake and storage from the bacterioferritin viewpoint

被引:214
作者
Carrondo, MA [1 ]
机构
[1] Univ Nova Lisboa, Inst Tecnol Quim & Biol, P-2784505 Oeiras, Portugal
关键词
bacterioferritins; ferroxidase activity; iron storage; native di-iron centres; specific iron channel;
D O I
10.1093/emboj/cdg215
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ferritins constitute a broad superfamily of iron storage proteins, widespread in all domains of life, in aerobic or anaerobic organisms. Ferritins isolated from bacteria may be haem-free or contain a haem. In the latter case they are called bacterioferritins. The primary function of ferritins inside cells is to store iron in the ferric form. A secondary function may be detoxification of iron or protection against O-2 and its radical products. Indeed, for bacterioferritins this is likely to be their primary function. Ferritins and bacteroferritins have essentially the same architecture, assembling in a 24mer cluster to form a hollow, roughly spherical construction. In this review, special emphasis is given to the structure of the ferroxidase centres with native iron-containing sites, since oxidation of ferrous iron by molecular oxygen takes place in these sites. Although present in other ferritins, a specific entry route for iron, coupled with the ferroxidase reaction, has been proposed and described in some structural studies. Electrostatic calculations on a few selected proteins indicate further ion channels assumed to be an entry route in the later mineralization processes of core formation.
引用
收藏
页码:1959 / 1968
页数:10
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