Increased activity and intranuclear expression of phospholipase D2 in human renal cancer

被引：116

作者：

Zhao, YT

Ehara, H

Akao, Y

Shamoto, M

Nakagawa, Y

Banno, Y

Deguchi, T

Ohishi, N

Yagi, K

Nozawa, Y ^{[1
]}

机构：

[1] Gifu Int Inst Biotechnol, Gifu 5050116, Japan

[2] Inst Appl Biochem, Gifu 5050116, Japan

[3] Gifu Univ, Sch Med, Dept Biochem, Gifu 5008705, Japan

[4] Gifu Univ, Sch Med, Dept Urol, Gifu 5008705, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 278卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

phospholipase D2; intranuclear expression; tumorigenesis; renal cancer;

D O I：

10.1006/bbrc.2000.3719

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the PLD activities of human renal cancers and found that the PLD2 activity was greatly elevated in almost all cases examined as compared with the adjacent normal region. Western blot analysis showed the increased levels of PLD2 protein, but the PLD1 was not discernible. The oleate-dependent PLD activity was very low but appeared to increase in most cases. Interestingly, the immunohistochemical observations indicated the high expression of PLD2 in the nuclei of clear carcinoma cells. This is the first demonstration which suggests the possible involvement of PLDS in tumorigenesis of renal cancer. (C) 2000 Academic Press.

引用

页码：140 / 143

页数：4

共 23 条

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