Decoding the function of nuclear long non-coding RNAs

被引：248

作者：

Chen, Ling-Ling ^{[1
]}

Carmichael, Gordon G. ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Stem Cell Inst, Farmington, CT 06030 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 03期

关键词：

INACTIVE-X; BIDIRECTIONAL PROMOTERS; GENE-EXPRESSION; ALU RNA; TRANSCRIPTION; REVEALS; GENOME; PARASPECKLES; REPRESSION; REPEATS;

D O I：

10.1016/j.ceb.2010.03.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Long non-coding RNAs (IncRNAs) are mRNA-like, non-protein-coding RNAs that are pervasively transcribed throughout eukaryotic genomes. Rather than silently accumulating in the nucleus, many of these are now known or suspected to play important roles in nuclear architecture or in the regulation of gene expression. In this review, we highlight some recent progress in how IncRNAs regulate these important nuclear processes at the molecular level.

引用

页码：357 / 364

页数：8

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