Pharmacokinetics of indomethacin in poultry

被引:10
作者
Cristòfol, C [1 ]
Valladares, JE
Martí, G
Arboix, M
机构
[1] UAB, Fac Vet, Dept Farmacol & Terapeut, Bellaterra 08193, Spain
[2] Lab JAER SA, St Vicenc Dels Horts 08241, Spain
关键词
indomethacin; poultry; broiler; pharmacokinetics; plasma concentrations; disposition;
D O I
10.2307/1592528
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Indomethacin (INDO) is a nonsteroidal antiinflammatory drug widely used since the 1970s. The pharmacokinetic behavior of INDO (2 mg/kg) has been studied after intravenous (IV) and oral administration to broiler chickens. After IV administration, a first fast distribution phase and a later and slower elimination phase were observed. The elimination half-lift and mean residence time (MRT) obtained were 1.0 hr and 0.8 hr, respectively. After oral administration, a flip-flop phenomenon was observed giving an elimination half-life and MRT approximately three times and six times higher, respectively, than the IV administration. The plasma concentrations after oral administration were sustained during 8-10 hr, giving an antinflammatory cover over the dose producing 50% of maximal effect during this time period.
引用
收藏
页码:210 / 214
页数:5
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