B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LTR192G in H-pylori seronegative individuals

被引：30

作者：

Losonsky, GA

Kotloff, KL

Walker, RI

机构：

[1] Dept Pediat, Div Infect Dis & Trop Pediat, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Ctr Vaccine Dev, Hlth Sci Facil, Baltimore, MD 21201 USA

[3] Antex Biol Inc, Gaithersburg, MD USA

来源：

VACCINE | 2003年 / 21卷 / 5-6期

关键词：

Helicobacter pylori; B cell responses; gastric antrum and duodenum;

D O I：

10.1016/S0264-410X(02)00259-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate whether B cell-specific responses could be elicited in the gastric mucosa of Helicobacterpylori (HP) naive subjects, five volunteers ingested three doses of a HP killed whole cell (HWC) vaccine with 25 mug of recombinant heat-labile toxin (LTR192G). TWO Of three subjects had detectable LTR192G and HWC IgA antibody secreting cell (ASC) gastric responses. LTR192G and HWC responses in duodenal were 5-14-fold higher than those detected in antral biopsies (P < 0.01 and P = 0.05, respectively). These results provide the first evidence that specific gastric B cell responses can be induced in HP-non-infected individuals following oral immunization. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：562 / 565

页数：4

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