Alzheimer's disease -: A technical KO of amyloid-β peptide

被引：52

作者：

Haass, C

Selkoe, DJ

机构：

[1] Cent Inst Mental Hlth, Dept Biol Mol, D-68159 Mannheim, Germany

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

NATURE | 1998年 / 391卷 / 6665期

关键词：

D O I：

10.1038/34800

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutations in the presenilin-1 gene (PS1) cause an aggressive form of familial Alzheimer's disease, and a new study goes some way to showing how. The authors created PS1 knockout mice, and found that they produced 80 per cent less amyloid-beta peptide (the protein that accumulates to form senile plaques) than normal mice. They propose that presenilin-1 normally stimulates production of amyloid-beta peptide by activating alpha-secretase-mediated cleavage of the amyloid precursor protein.

引用

收藏

页码：339 / 340

页数：2

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