A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium

被引：165

作者：

Xi, RW ^{[1
]}

McGregor, JR ^{[1
]}

Harrison, DA ^{[1
]}

机构：

[1] Univ Kentucky, Dept Biol, Lexington, KY 40506 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 4卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1534-5807(02)00412-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Drosophila egg develops through closely coordinated activities of associated germline and somatic cells. An essential aspect of egg development is the differentiation of the somatic follicle cells into several distinct subpopulations with specific functions. Here we demonstrate that the graded activity of the Janus kinase (JAK) pathway, stimulated by the Unpaired ligand, patterns the anterior-posterior axis of the follicular epithelium. Different levels of JAK activity instruct adoption of distinct anterior cell fates. Further, the coordinated activities of the JAK/STAT and epidermal growth factor receptor (EGFR) pathways are required to specify the posterior terminal cell fate. We propose that Upd secreted from the polar cells may act as a morphogen to stimulate A/P-derived follicular fates through JAK pathway activation.

引用

页码：167 / 177

页数：11

共 39 条

[1] The Drosophila STAT protein, Stat92E, regulates follicle cell differentiation during oogenesis [J].