Expanding the scope of drug repurposing in pediatrics: The Children's Pharmacy Collaborative™

被引：14

作者：

Blatt, Julie ^{[1
,2
]}

Farag, Sherif ^{[3
]}

Corey, Seth J. ^{[4
]}

Sarrimanolis, Zafeira ^{[3
]}

Muratov, Eugene ^{[3
]}

Fourches, Denis ^{[3
]}

Tropsha, Alexander ^{[3
]}

Janzen, William P. ^{[2
,3
]}

机构：

[1] Univ N Carolina, Div Pediat Hematol Oncol, Chapel Hill, NC 27514 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

[3] Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC USA

[4] Northwestern Univ, Feinberg Sch Med, Div Pediat Hematol Oncol, Childrens Mem Hosp,Robert H Lurie Comprehens Canc, Chicago, IL 60611 USA

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 11期

关键词：

ONCOLOGY;

D O I：

10.1016/j.drudis.2014.08.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drug repurposing is the use of 'old' drugs for new indications, avoiding the need for time- and cost-intensive toxicity studies. This approach should be particularly attractive for pediatrics, but its use in this population has been limited. One obstacle has been the lack of a comprehensive database of drugs for which there already is at least one indication in children. We describe the development of The Children's Pharmacy Collaborative (TM), which should grow over time, serve as a resource for professionals and families, and stimulate drug-repurposing efforts for a range of pediatric disorders.

引用

页码：1696 / 1698

页数：3

共 9 条

[1]

[Anonymous], HARRIET LANE HDB

[2] Drug repurposing in pediatrics and pediatric hematology oncology [J].

Blatt, Julie ;

Corey, Seth J. .

DRUG DISCOVERY TODAY, 2013, 18 (1-2) :4-10

[3] New uses for old drugs [J].

Chong, Curtis R. ;

Sullivan, David J., Jr. .

NATURE, 2007, 448 (7154) :645-646

[4] Trust, But Verify: On the Importance of Chemical Structure Curation in Cheminformatics and QSAR Modeling Research [J].

Fourches, Denis ;

Muratov, Eugene ;

Tropsha, Alexander .

JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2010, 50 (07) :1189-1204

[5] Obtaining and screening compound collections: a user's guide and a call to chemists [J].

Hergenrother, PJ .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2006, 10 (03) :213-218

[6] Propranolol for severe hemangiomas of infancy [J].

Leaute-Labreze, Christine ;

de la Roque, Eric Dumas ;

Hubiche, Thomas ;

Boralevi, Franck ;

Thambo, Jean-Benoit ;

Taieb, Alain .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (24) :2649-2651

[7] A proposed modification to the best pharmaceuticals for Children Act to benefit pediatric oncology [J].

Needle, Michael N. .

PEDIATRIC BLOOD & CANCER, 2012, 59 (01) :3-4

[8]

Oprea Tudor I, 2011, Drug Discov Today Ther Strateg, V8, P61

[9] How to improve R&D productivity: the pharmaceutical industry's grand challenge [J].

Paul, Steven M. ;

Mytelka, Daniel S. ;

Dunwiddie, Christopher T. ;

Persinger, Charles C. ;

Munos, Bernard H. ;

Lindborg, Stacy R. ;

Schacht, Aaron L. .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (03) :203-214

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