An evaluation of botulinum-A toxin injections to improve upper extremity function in children with hemiplegic cerebral palsy

被引:156
作者
Fehlings, D
Rang, M
Glazier, J
Steele, C
机构
[1] Bloorview MacMillan Ctr, Dept Pediat, Div Neurol & Gen Pediat, Toronto, ON M4G 1R8, Canada
[2] Bloorview MacMillan Ctr, Dept Surg, Div Orthoped, Toronto, ON M4G 1R8, Canada
[3] Hosp Sick Children, Toronto, ON M5G 1X8, Canada
关键词
D O I
10.1067/mpd.2000.108393
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: In a randomized, controlled, single-blind trial, to test the hypothesis that botulinum-A toxin (BTA) injections into the upper extremity of children with spastic hemiplegia improve upper extremity function. Study design: Thirty children with hemiplegia, aged 2.5 to 10 years, were randomly assigned to receive: (1) a BTA injection into 1 or more of 3 muscle groups (biceps, volar forearm muscles, adductor pollicis) plus occupational therapy or (2) occupational therapy alone. Blinded outcomes obtained at baseline and at 1, 3, and 6 months included the Quality of Upper Extremity Skills Test (QUEST), goniometry measurements, grip strength, and Ashworth scores. The caregiver completed the self-care domain of the Pediatric Evaluation of Disability Inventory. Results: Twenty-nine subjects completed the study. The QUEST demonstrated a significant improvement favoring the treatment group on a 2-way analysis of variance (F = 4.69, H = 1,83; P = .039). BTA treatment was also associated with an improvement in score on the self-care domain of the Pediatric Evaluation of Disability Inventory (F = 4.68, H = 1,82; P = .04). Conclusions: This study supports the effectiveness of BTA injections to improve upper extremity function of children with hemiplegia who have at least moderate spasticity.
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页码:331 / 337
页数:7
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