Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: A case report

被引：28

作者：

Mann, D ^{[1
]}

Moreb, J ^{[1
]}

Smith, S ^{[1
]}

Gian, V ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL 32610 USA

来源：

JOURNAL OF INFECTION | 1998年 / 36卷 / 02期

关键词：

D O I：

10.1016/S0163-4453(98)80021-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report a case of fatal adenovirus infection in a 37-year-old female who underwent allogeneic bone marrow transplantation (BMT) for acute myelogenous leukaemia (AML), Post BMT she developed acute grade II graft-vs.-host disease (aGVHD) requiring high-dose steroids and anti-thymocyte globulin, Additionally, her clinical course was complicated with adenovirus-associated haemorrhagic cystitis and viraemia. Intravenous ribavirin was obtained and administered for 5 days without success; the patient's mental status deteriorated rapidly and she died on day 69 post-transplant, Radiological imaging revealed diffuse cortical necrosis. At autopsy adenovirus was identified in her bladder, kidneys and lungs.

引用

页码：227 / 228

页数：2

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