Stereoselective syntheses of the rhizoxin C(1)-C(9) and C(12)-C(26) subunits

被引：16

作者：

Burke, SD ^{[1
]}

Hong, J ^{[1
]}

Mongin, AP ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 16期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)00268-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective syntheses of the C(1)-C(9) and C(12)-C(26) subunits of the macrolide antitumor agent rhizoxin are described. Chelation-controlled Ireland-Claisen rearrangement, stereoselective Horner-Wadsworth-Emmons reactions and a thermodynamically-controlled diastereotopic group differentiation are featured. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2239 / 2242

页数：4

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