Can Animal Models of Disease Reliably Inform Human Studies?

被引：898

作者：

van der Worp, H. Bart ^{[1
]}

Howells, David W. ^{[2
,3
]}

Sena, Emily S. ^{[2
,3
,4
]}

Porritt, Michelle J. ^{[2
,3
]}

Rewell, Sarah ^{[2
,3
]}

O'Collins, Victoria ^{[2
,3
]}

Macleod, Malcolm R. ^{[4
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Neurol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands

[2] Natl Stroke Res Inst, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

[4] Univ Edinburgh, Dept Clin Neurosci, Edinburgh, Midlothian, Scotland

来源：

PLOS MEDICINE | 2010年 / 7卷 / 03期

基金：

英国医学研究理事会;

关键词：

EXPERIMENTAL ISCHEMIC-STROKE; RANDOMIZED-TRIALS; EMPIRICAL-EVIDENCE; METHODOLOGICAL QUALITY; INFARCT SIZE; METAANALYSIS; BIAS; EFFICACY; DESIGN; RESTRICTION;

D O I：

10.1371/journal.pmed.1000245

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：1 / 8

页数：8

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