A profound deficiency in thymic progenitor cells in mice lacking Jak3

被引：26

作者：

Baird, AM ^{[1
]}

Lucas, JA ^{[1
]}

Berg, LJ ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA

来源：

JOURNAL OF IMMUNOLOGY | 2000年 / 165卷 / 07期

关键词：

D O I：

10.4049/jimmunol.165.7.3680

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humans and mice with genetic deficiencies that lead to loss of signaling through common gamma-chain (gamma c)-containing cytokine receptors have severe defects in B and T lymphocytes. In humans, these deficiencies lead to a complete absence of T cells, whereas in mice, small thymuses give rise to normal numbers of peripheral T cells. We have examined the first wave of developing T cells in Jak3(-/-), IL-7(-/-), mad IL-7R alpha(-/-) fetal mice, and have found a near absence of thymic progenitor cells. This deficiency is highlighted by the complete inability of Jak3(-/-) progenitor cells to reconstitute T cell development in the presence of competing wild-type cells. These data clearly demonstrate a strong common basis for the T cell deficiencies in mice and humans lacking gamma c/Jak3 signaling pathways.

引用

页码：3680 / 3688

页数：9

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