G proteins and hypertension: An alternative candidate gene approach

被引:23
作者
Siffert, W [1 ]
机构
[1] Univ Essen Gesamthsch Klinikum, Inst Pharmakol, D-45122 Essen, Germany
关键词
essential hypertension; blood pressure; immortalized cells; intracellular signal transduction; polygenetic disorder;
D O I
10.1046/j.1523-1755.1998.00934.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Hypertension affects approximately 20 to 30% of individuals in industrialized countries, and is commonly believed to develop on the basis of both genetic and environmental factors. The identification of genes susceptibile to the most frequent form of hypertension, commonly referred to as "essential" hypertension, is hampered by the fact that blood pressure is a poorly defined phenotype that is modulated by multiple factors, such as gender, race, body mass etc., and that the definition of hypertension depends on a rather arbitrarily chosen cut-off value. Hence, more progress has been made in the identification of genes responsible for rare autosomal dominant forms of hypertension, such as Liddle's disease. This review focuses on an experimental approach that attempts to define candidate genes for essential hypertension using immortalized cells from well characterized normotensive and hypertensive subjects. From the presently available results, one attractive speculation is that an increased intracellular signal transduction caused by an enhanced reactivity of G(i)-type G proteins represents a genetically fixed trait that renders affected individuals susceptible to essential hypertension.
引用
收藏
页码:1466 / 1470
页数:5
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