Novel phenyl nitrogen mustard and half-mustard derivatives of distamycin A

被引：19

作者：

Cozzi, P

Beria, I

Biasoli, G

Caldarelli, M

Capolongo, L

D'Alessio, R

Geroni, C

Mazzini, S

Ragg, E

Rossi, C

Mongelli, N

机构：

[1] Pharmacia & Upjohn Inc, Preclin Res, Therapeut Area Oncol & Immunol, I-20014 Nerviano, Milan, Italy

[2] Univ Milan, Fac Agr, Dept Mol Sci, I-20122 Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(97)10121-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design, synthesis, in vitro and in vivo activities of novel benzoyl and cinnamoyl nitrogen mustard and half-mustard derivatives of distamycin A are described and structure-activity relationships are discussed. The equipotent activities of N-ethyl-N-chloroethyl half-mustards and N,N-dichloroethyl mustards and the superior activities of cinnamoyl derivatives are the most relevant features of the series. (C) 1997 Elsevier Science Ltd.

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页码：2985 / 2990

页数：6

相关论文

共 24 条

[1] STRUCTURE + SYNTHESIS OF DISTAMYCIN A [J].

ARCAMONE, F ;

NICOLELL.V ;

PENCO, S ;

OREZZI, P ;

PIRELLI, A .

NATURE, 1964, 203 (494) :1064-+

[2]

Arcamone F, 1967, GAZZ CHIM ITAL, V97, P1097

[3] SYNTHESIS, DNA-BINDING PROPERTIES, AND ANTITUMOR-ACTIVITY OF NOVEL DISTAMYCIN DERIVATIVES [J].

ARCAMONE, FM ;

ANIMATI, F ;

BARBIERI, B ;

CONFIGLIACCHI, E ;

DALESSIO, R ;

GERONI, C ;

GIULIANI, FC ;

LAZZARI, E ;

MENOZZI, M ;

MONGELLI, N ;

PENCO, S ;

VERINI, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (04) :774-778

[4]

ARISTOFF PA, 1993, ADV MED CHEM, V2, P67

[5] Structure-activity relationship of novel tallimustine derivatives: Synthesis and antitumor activity [J].

Baraldi, PG ;

Beria, I ;

Cacciari, B ;

Capolongo, L ;

Cozzi, P ;

Mongelli, N ;

Romagnoli, R ;

Spalluto, G .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (11) :1247-1252

[6] Synthesis and antitumor activity of novel distamycin derivatives [J].

Baraldi, PG ;

Beria, I ;

Cacciari, B ;

Cozzi, P ;

Franzetti, C ;

Mongelli, N ;

Romagnoli, R ;

Spalluto, G .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (11) :1241-1246

[7] A STUDY OF COMPARATIVE CHEMICAL AND BIOLOGICAL ACTIVITIES OF ALKYLATING AGENTS [J].

BARDOS, TJ ;

DATTAGUP.N ;

HEBBORN, P ;

TRIGGLE, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (02) :167-&

[8] RELATIONSHIPS BETWEEN FUNCTIONALITY AND GENETIC TOXICOLOGY OF SELECTED DNA-DAMAGING AGENTS [J].

BRENDEL, M ;

RUHLAND, A .

MUTATION RESEARCH, 1984, 133 (01) :51-85

[9] DNA SEQUENCE-SPECIFIC ADENINE ALKYLATION BY THE NOVEL ANTITUMOR DRUG TALLIMUSTINE (FCE-24517), A BENZOYL NITROGEN-MUSTARD DERIVATIVE OF DISTAMYCIN [J].

BROGGINI, M ;

COLEY, HM ;

MONGELLI, N ;

PESENTI, E ;

WYATT, MD ;

HARTLEY, JA ;

DINCALCI, M .

NUCLEIC ACIDS RESEARCH, 1995, 23 (01) :81-87

[10] Backbone and benzoyl mustard carrying moiety modifies DNA interactions of distamycin analogues [J].

Ciucci, A ;

Manzini, S ;

Lombardi, P ;

Arcamone, F .

NUCLEIC ACIDS RESEARCH, 1996, 24 (02) :311-315