;Protective effect of collagen derivates on the ulcerative lesions caused by oral administration of ethanol

被引：11

作者：

Castro, G. A.

Sgarbieri, V. C.

Carvalho, J. E.

Tinti, S. V.

Possenti, A.

机构：

[1] Univ Estadual Campinas, Dept Alimentos & Nutr, Fac Engn Alimentos, Campinas, SP, Brazil

[2] Univ Estadual Campinas, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, Campinas, SP, Brazil

来源：

JOURNAL OF MEDICINAL FOOD | 2007年 / 10卷 / 01期

关键词：

collagen hydrolysates; mucosa protection; ulcerative lesions; ulcerogenic agent;

D O I：

10.1089/jmf.2006.262

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protocol employed a negative and a positive control and a single dose of the experimental samples given by intragastric intubation. The beef collagen did not present a dose-response correlation in the ethanol model, whereas pig collagen showed a logarithmic dose-response relationship. Beef collagen hydrolysate decreased the ulcerative lesion index of 55% versus a 61% decrease for pig collagen hydrolysate at the same dosage (750 mg/ kg of body weight). No significant differences were found (P > .05) between the hydrolysates and their fractions.

引用

页码：154 / 158

页数：5

共 16 条

[1]

Gastric mucosal integrity:: gastric mucosal blood flow and microcirculation.: An overview [J].