Comparison of antibiotic susceptibility of Burkholderia cepacia complex organisms when grown planktonically or as biofilm in vitro

被引：76

作者：

Caraher, E.

Reynolds, G.

Murphy, P.

McClean, S.

Callaghan, M. ^{[1
]}

机构：

[1] ITT, Dept Appl Sci, Dublin 24, Ireland

[2] ITT, NICB, Dublin 24, Ireland

[3] Adelaide Meath Inc Natl Childrens Hosp AMNCH, Dublin 24, Ireland

[4] Trinity Coll Dublin, Dept Clin Microbiol, Dublin 2, Ireland

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2007年 / 26卷 / 03期

关键词：

D O I：

10.1007/s10096-007-0256-x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study determined the antibiotic susceptibility of planktonic and biofilm cultures of Burkholderia cepacia complex organisms, a group of highly problematic pathogens associated with cystic fibrosis patients. The biofilm inhibitory concentrations were considerably higher than the corresponding minimum inhibitory concentrations for meropenem and piperacillin-tazobactam. However, tobramycin and amikacin were efficacious against both biofilm and planktonic cultures. Overall this study showed that biofilm susceptibility testing might be more clinically appropriate for determining antibiotic therapy for Burkholderia cepacia complex infections in cystic fibrosis patients.

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页码：213 / 216

页数：4

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