Distressing bacteria:: Structure of a prokaryotic detox program

被引:8
作者
de la Cueva-Méndez, G [1 ]
机构
[1] MRC, Canc Cell Unit, Hutchison Res Ctr, Cambridge CB2 2XZ, England
关键词
D O I
10.1016/S1097-2765(03)00146-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
MazF and MazE are components of a chromosomal toxin-antitoxin system of Escherichia coli. In this issue of Molecular Cell, Kamada et al. describe the crystal structure of a MazE/MazF heterohexamer and propose that the mechanism of toxin-antidote recognition is common to other homologous chromosomal and plasmid-borne systems.
引用
收藏
页码:848 / 850
页数:3
相关论文
共 10 条
[1]   Intricate interactions within the ccd plasmid addiction system [J].
Dao-Thi, MH ;
Charlier, D ;
Loris, R ;
Maes, D ;
Messens, J ;
Wyns, L ;
Backmann, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (05) :3733-3742
[2]   Regulatable killing of eukaryotic cells by the prokaryotic proteins Kid and Kis [J].
de la Cueva-Méndez, G ;
Mills, AD ;
Clay-Farrace, L ;
Díaz-Orejas, R ;
Laskey, RA .
EMBO JOURNAL, 2003, 22 (02) :246-251
[3]   Addiction modules and programmed cell death and antideath in bacterial cultures [J].
Engelberg-Kulka, H ;
Glaser, G .
ANNUAL REVIEW OF MICROBIOLOGY, 1999, 53 :43-70
[4]   Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress [J].
Gerdes, K .
JOURNAL OF BACTERIOLOGY, 2000, 182 (03) :561-572
[5]   Structural and functional analysis of the Kid toxin protein from E-coli plasmid R1 [J].
Hargreaves, D ;
Santos-Sierra, S ;
Giraldo, R ;
Sabariegos-Jareño, R ;
de la Cueva-Méndez, G ;
Boelens, R ;
Díaz-Orejas, R ;
Rafferty, JB .
STRUCTURE, 2002, 10 (10) :1425-1433
[6]   COMPARISON OF CCD OF F, PARDE OF RP4, AND PARD OF R1 USING A NOVEL CONDITIONAL REPLICATION CONTROL-SYSTEM OF PLASMID R1 [J].
JENSEN, RB ;
GROHMANN, E ;
SCHWAB, H ;
DIAZOREJAS, R ;
GERDES, K .
MOLECULAR MICROBIOLOGY, 1995, 17 (02) :211-220
[7]   Crystal structure of the MazE/MazF complex: Molecular bases of antidote-toxin recognition [J].
Kamada, K ;
Hanaoka, F ;
Burley, SK .
MOLECULAR CELL, 2003, 11 (04) :875-884
[8]   Crystal structure of CcdB, a topoisomerase poison from E-coli [J].
Loris, R ;
Dao-Thi, MH ;
Bahassi, EM ;
Van Melderen, L ;
Poortmans, F ;
Liddington, R ;
Couturier, M ;
Wyns, L .
JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (04) :1667-1677
[9]   The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome [J].
Marianovsky, I ;
Aizenman, E ;
Engelberg-Kulka, H ;
Glaser, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (08) :5975-5984
[10]   Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins [J].
Pedersen, K ;
Christensen, SK ;
Gerdes, K .
MOLECULAR MICROBIOLOGY, 2002, 45 (02) :501-510