Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins

被引：55

作者：

Seeger, M ^{[1
]}

Hartmann-Petersen, R ^{[1
]}

Wilkinson, CRM ^{[1
]}

Wallace, M ^{[1
]}

Samejima, I ^{[1
]}

Taylor, MS ^{[1
]}

Gordon, C ^{[1
]}

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2003年 / 278卷 / 19期

关键词：

D O I：

10.1074/jbc.M208281200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fission yeast Rhp23 and Pus1 represent two families of multiubiquitin chain-binding proteins that associate with the proteasome. We show that both proteins bind to different regions of the proteasome subunit Mts4. The binding site for Pus1 was mapped to a cluster of repetitive sequences also found in the proteasome subunit SpRpn2 and the anaphase-promoting complex/cyclosome (APC/C) subunit Cut4. The putative role of Pus1 as a factor involved in allocation of ubiquitinylated substrates for the proteasome is discussed.

引用

页码：16791 / 16796

页数：6

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