The role of human and viral cytokines in the pathogenesis of multiple myeloma

被引：13

作者：

Berenson, JR

Sjak-Shie, NN

Vescio, RA

机构：

[1] Cedars Sinai Med Ctr, Div Hematol & Oncol, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Med, Dept Med, Los Angeles, CA 90024 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2000年 / 10卷 / 05期

关键词：

cytokines; HHV-8; multiple myeloma;

D O I：

10.1006/scbi.2000.0332

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple myeloma (MM) is characterized by the accumulation of,monoclonal plasma cells, a terminally differentiated form of B lymphocyte in the bone marrow. This disease is most often associated with bone destruction, anemia and renal failure. Besides the malignant plasma cells, it has become clear that nonmalignant cells in the bone marrow also contribute to the development of this malignancy bit the release of cytokines. Further. support for. the importance of the supporting cells comes from our recent finding of the human herpesvirus 8 (HHV-8) in the nonmalignant bone marrow stromal cells from these patients.

引用

页码：383 / 391

页数：9

共 97 条

[1] Detection of human herpesvirus-8 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenstrom's macroglobulinemia [J].