Modulation of bone remodeling by active vitamin D: its role in the treatment of osteoporosis

被引：8

作者：

Ikeda, K

Ogata, E

机构：

[1] Natl Inst Lonev Sci, Dept Geriatr Res, Aichi 4748522, Japan

[2] Japanese Fdn Canc Res, Canc Inst Hosp, Tokyo 1708455, Japan

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2000年 / 116卷 / 2-3期

关键词：

active vitamin D; osteoporosis; bone resorption; bone formation;

D O I：

10.1016/S0047-6374(00)00115-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Active vitamin D drugs are used for the treatment of osteoporosis in a number of countries, including Japan. However, their use is controversial. Here, we briefly discuss two issues that are important for understanding the role of active vitamin D (rather than plain vitamin D) in the treatment of osteoporosis: (1) whether or not its skeletal effects are mediated solely through its effects on intestinal calcium absorption in calcium- and vitamin D-replete states, and (2) how it modulates the bone remodeling process. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：103 / 111

页数：9

共 24 条

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