Posttraumatic stress and lifestyles are associated with natural killer cell activity in victims of the Hanshin-Awaji earthquake in Japan

被引:40
作者
Inoue-Sakurai, C [1 ]
Maruyama, S [1 ]
Morimoto, K [1 ]
机构
[1] Osaka Univ, Grad Sch Med, Dept Social & Environm Med, Suita, Osaka 5650871, Japan
关键词
Hanshin-Awaji earthquake; NK cell activity; PTSD symptoms; lifestyles;
D O I
10.1006/pmed.2000.0744
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background. The relationships among mental health status, lifestyle, and natural killer (NK) cell activity, which plays important roles in the immune surveillance of tumors and viral infections, were investigated in victims of the Hanshin-Awaji Earthquake. Methods, About 1 and 1/3 years after the earthquake, 155 male workers who experienced the event were administered questionnaires concerning their unhealthy mental status, such as symptoms of posttraumatic stress disorder (PTSD), lifestyles, and demographic variables, Peripheral blood was taken from all of them to measure NK cell activity. Results. Subjects who had PTSD symptoms showed lower NK cell activity than those without symptoms. Subjects with positive lifestyles showed higher NK cell activity than those with poor or moderate lifestyles. When subjects were divided into four groups by lifestyle and PTSI) symptoms, subjects with positive lifestyles and few or no PTSD symptoms showed the highest NK cell activity among the four groups, The other three groups were subjects with positive lifestyles but many PTSD symptoms; subjects with poor or moderate lifestyles and many PTSI) symptoms; and subjects with poor or moderate lifestyles and few or no PTSD symptoms, Conclusion, PTSD symptoms and lifestyles were associated with NK cell activity in the earthquake victims, (C) 2000 American Health Foundation and Academic Press.
引用
收藏
页码:467 / 473
页数:7
相关论文
共 41 条
[1]   POSTNATAL EXPANSION OF THE NATURAL-KILLER AND KILLER CELL-POPULATION IN HUMANS IDENTIFIED BY THE MONOCLONAL HNK-1 ANTIBODY [J].
ABO, T ;
COOPER, MD ;
BALCH, CM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (01) :321-326
[2]  
Ader R., 1991, PSYCHONEUROIMMUNOLOG
[3]  
American Psychiatric Association, 1995, DIAGN STAT MAN MENT
[4]   IMMUNE FUNCTION IN UNEMPLOYED WOMEN [J].
ARNETZ, BB ;
WASSERMAN, J ;
PETRINI, B ;
BRENNER, SO ;
LEVI, L ;
ENEROTH, P ;
SALOVAARA, H ;
HJELM, R ;
SALOVAARA, L ;
THEORELL, T ;
PETTERSON, IL .
PSYCHOSOMATIC MEDICINE, 1987, 49 (01) :3-12
[5]  
BARTROP RW, 1977, LANCET, V1, P834
[6]  
Belloc N B, 1973, Prev Med, V2, P67, DOI 10.1016/0091-7435(73)90009-1
[7]  
Belloc N B, 1972, Prev Med, V1, P409, DOI 10.1016/0091-7435(72)90014-X
[8]  
Berkman L.F., 1983, HLTH WAYS LIVING ALA
[9]   10-YEAR MORTALITY STUDY OF THE POPULATION INVOLVED IN THE SEVESO INCIDENT IN 1976 [J].
BERTAZZI, PA ;
ZOCCHETTI, C ;
PESATORI, AC ;
GUERCILENA, S ;
SANARICO, M ;
RADICE, L .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 129 (06) :1187-1200
[10]  
BOYUM A, 1968, SCAND J CLIN LAB I S, V97, P21