Development in motion: Helper T cells at work

被引：221

作者：

Reiner, Steven L. ^{[1
]}

机构：

[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

来源：

CELL | 2007年 / 129卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.03.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammals, helper T cells orchestrate defense against diverse pathogens. However, these warriors of the immune system can also result in self-inflicted injury culminating in autoimmune and allergic diseases. Recent findings-such as the discovery of the Th17 lineage-have revealed additional complexity in the fates chosen by helper T cells and have begun to reshape our view of how signaling and transcriptional networks generate appropriate and inappropriate immunity.

引用

页码：33 / 36

页数：4

共 20 条

[1] An epigenetic view of helper T cell differentiation
Ansel, KM
Lee, DU
Rao, A
[J]. NATURE IMMUNOLOGY, 2003, 4 (07) : 616 - 623
[2] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E
Carrier, YJ
Gao, WD
Korn, T
Strom, TB
Oukka, M
Weiner, HL
Kuchroo, VK
[J]. NATURE, 2006, 441 (7090) : 235 - 238
[3] Helper T cell differentiation is controlled by the cell cycle
Bird, JJ
Brown, DR
Mullen, AC
Moskowitz, NH
Mahowald, MA
Sider, JR
Gajewski, TF
Wang, CR
Reiner, SL
[J]. IMMUNITY, 1998, 9 (02) : 229 - 237
[4] Asymmetric T lymphocyte division in the initiation of adaptive immune responses
Chang, John T.
Palanivel, Vikram R.
Kinjyo, Ichiko
Schambach, Felix
Intlekofer, Andrew M.
Banerjee, Arnob
Longworth, Sarah A.
Vinup, Kristine E.
Mrass, Paul
Oliaro, Jane
Killeen, Nigel
Orange, Jordan S.
Russell, Sarah M.
Weninger, Wolfgang
Reiner, Steven L.
[J]. SCIENCE, 2007, 315 (5819) : 1687 - 1691
[5] Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Cua, DJ
Sherlock, J
Chen, Y
Murphy, CA
Joyce, B
Seymour, B
Lucian, L
To, W
Kwan, S
Churakova, T
Zurawski, S
Wiekowski, M
Lira, SA
Gorman, D
Kastelein, RA
Sedgwick, JD
[J]. NATURE, 2003, 421 (6924) : 744 - 748
[6] Opinion - Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
Dong, C
[J]. NATURE REVIEWS IMMUNOLOGY, 2006, 6 (04) : 329 - 333
[7] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
Duerr, Richard H.
Taylor, Kent D.
Brant, Steven R.
Rioux, John D.
Silverberg, Mark S.
Daly, Mark J.
Steinhart, A. Hillary
Abraham, Clara
Regueiro, Miguel
Griffiths, Anne
Dassopoulos, Themistocles
Bitton, Alain
Yang, Huiying
Targan, Stephan
Datta, Lisa Wu
Kistner, Emily O.
Schumm, L. Philip
Lee, Annette T.
Gregersen, Peter K.
Barmada, M. Michael
Rotter, Jerome I.
Nicolae, Dan L.
Cho, Judy H.
[J]. SCIENCE, 2006, 314 (5804) : 1461 - 1463
[8] Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Harrington, LE
Hatton, RD
Mangan, PR
Turner, H
Murphy, TL
Murphy, KM
Weaver, CT
[J]. NATURE IMMUNOLOGY, 2005, 6 (11) : 1123 - 1132
[9] The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
Ivanov, Ivaylo I.
McKenzie, Brent S.
Zhou, Liang
Tadokoro, Carlos E.
Lepelley, Alice
Lafaille, Juan J.
Cua, Daniel J.
Littman, Dan R.
[J]. CELL, 2006, 126 (06) : 1121 - 1133
[10] IL-23 promotes tumour incidence and growth
Langowski, John L.
Zhang, Xueqing
Wu, Lingling
Mattson, Jeanine D.
Chen, Taiying
Smith, Kathy
Basham, Beth
McClanahan, Terrill
Kastelein, Robert A.
Oft, Martin
[J]. NATURE, 2006, 442 (7101) : 461 - 465

← 1 2 →