Early intervention in post-transplant lymphoproliferative disorders based on Epstein-Barr viral load

被引：30

作者：

Hoshino, Y

Kimura, H

Kuzushima, K

Tsurumi, T

Nemoto, K

Kikuta, A

Nishiyama, Y

Kojima, S

Matsuyama, T

Morishima, T

机构：

[1] Nagoya Univ, Sch Med, Dept Pediat, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Sch Med, Dept Dev Pediat, Nagoya, Aichi 4668550, Japan

[3] Nagoya Univ, Sch Med, Dept Hlth Sci, Nagoya, Aichi 4668550, Japan

[4] Nagoya Univ, Sch Med, Virol Lab, Dis Mechanism & Control Res Inst, Nagoya, Aichi 4668550, Japan

[5] Aichi Canc Ctr, Lab Viral Oncol, Res Inst, Nagoya, Aichi 464, Japan

[6] Japanese Red Cross Nagoya First Hosp, Div Hematol Oncol, Nagoya, Aichi, Japan

[7] Fukushima Med Univ, Dept Pediat, Fukushima, Japan

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 02期

基金：

日本学术振兴会;

关键词：

EBV; lymphoproliferative disorders; viral load; specific immunity;

D O I：

10.1038/sj.bmt.1702492

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Using a real-time quantitative PCR assay, we identified two patients with EBV-related lymphoproliferative disorders at a very early stage, Both had received an unmanipulated bone marrow transplant with antithymocyte globulin for conditioning, To estimate virus-specific immunity, the frequencies of EBV-specific CD8(+) T cells,were measured using an enzyme-linked immunospot assay, The frequencies of EBV-specific CD8(+) T cells of the two were 3.2 and 7.7%, respectively, which had possibly expanded in vivo. After withdrawing the immunosuppressive agents or administering donor lymphocytes transfusion, their symptoms regressed in parallel with the viral load.

引用

页码：199 / 201

页数：3

共 10 条

[1] B cell lymphoproliferative disorders following hematopoietic stem cell transplantation: risk factors, treatment and outcome [J].