Metabolizing enzyme genotype and risk for upper aerodigestive tract cancer

被引：36

作者：

Lazarus, P

Park, JY

机构：

[1] Univ S Florida, H Lee Moffitt Canc Ctr, Div Canc Control, Tampa, FL 33612 USA

[2] Univ S Florida, Div Mol Oncol, Tampa, FL 33612 USA

来源：

ORAL ONCOLOGY | 2000年 / 36卷 / 05期

关键词：

cytochrome P450s; glutathione S-transferases; epoxide hydrolase; N-acetyltransferases; alcohol dehydrogenase; acetylaldehyde dehydrogenase; oral cancer; laryngeal cancer; pharyngeal cancer; genetic susceptibility;

D O I：

10.1016/S1368-8375(00)00030-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic polymorphisms are associated with a number of enzymes involved in the metabolism of carcinogens important in the induction of upper aerodigestive tract cancer. It has been suggested that such polymorphisms may be linked to cancer susceptibility. Using a case-control molecular epidemiologic approach, the association between many of these genetic polymorphisms and susceptibility to upper aerodigestive tract cancer has been investigated in numerous studies. In this review, we summarize the findings of these studies, analyzing potential associations with upper aerodigestive tract cancer risk in terms of gene:environment interactions, genotype-induced functional defects in enzyme activity and/or expression, and the influence of race on these associations. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：421 / 431

页数：11

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