Centromere dynamics

被引：22

作者：

Bloom, Kerry ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2007年 / 17卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

HISTONE H3 VARIANT; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; CENP-A; PRECOCIOUS SEPARATION; KLUYVEROMYCES-LACTIS; CHROMATIN; NUCLEOSOME; KINETOCHORES; REPLICATION;

D O I：

10.1016/j.gde.2007.02.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

At the foundation of all eukaryotic kinetochores is a unique histone variant, known as CenH3 (centromere histone H3). We are starting to identify the histone chaperones responsible for CenH3 deposition at centromere DNA, and the mechanisms that restrict CenH3 from chromosome arms. The specialized nucleosome that contains CenH3 in place of canonical histone H3 lies at the interface between microtubules and chromosomes and directs kinetochore protein assembly. By contrast, pericentric chromatin is highly elastic and can stretch or recoil in response to microtubule shortening or growth in mitosis. The variety in histone modification is likely to play a key role in regulating the behavior of these distinct chromatin domains.

引用

页码：151 / 156

页数：6

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