Expression of MUPP1 protein in mouse brain

被引：24

作者：

Sitek, B

Poschmann, G

Schmidtke, K

Ullmer, C

Maskri, L

Andriske, M

Stichel, CC

Zhu, XR ^{[1
]}

Luebbert, H

机构：

[1] Ruhr Univ Bochum, Inst Anim Physiol, Dept Biol, D-44780 Bochum, Germany

[2] Biofrontera Pharmaceut AG, Leverkusen, Germany

来源：

BRAIN RESEARCH | 2003年 / 970卷 / 1-2期

关键词：

MUPP1; PDZ protein; 5-HT2; receptor; antiserum; mouse;

D O I：

10.1016/S0006-8993(03)02338-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Localizing cell surface receptors to specific subcellular sites can be crucial for proper functioning. PDZ proteins apparently play central roles in such protein localizations. 5-HT2C receptors have previously been shown to interact with MUPP1, a multi PDZ domain protein, in heterologous systems and in rat choroid plexus. We now report the generation and characterization of two independent MUPP1 antisera, which recognise distinct areas of the mouse brain in agreement with previous in-situ hybridization studies. Our results indicate that MUPP1 immunoreactivity co-localizes with 5-HT2A or 5-HT2C receptor expression in all regions of the mouse brain, including the choroid plexus where 5-HT2C receptors are highly enriched. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：178 / 187

页数：10

共 32 条

[1] Localization of the 5-hydroxytryptamine(2C) receptor protein in human and rat brain using specific antisera [J].