A placebo-controlled crossover trial of creatine in mitochondrial diseases

被引：65

作者：

Klopstock, T

Querner, V

Schmidt, F

Gekeler, F

Walter, M

Hartard, M

Hennig, M

Gasser, T

Pongratz, D

Straube, A

Dieterich, M

Müller-Felber, W

机构：

[1] Univ Munich, Dept Neurol, D-81366 Munich, Germany

[2] Univ Munich, Friedrich Baur Inst, D-81366 Munich, Germany

[3] Tech Univ Munich, Inst Med Stat & Epidemiol, Munich, Germany

[4] Tech Univ Munich, Dept Sports Med, Munich, Germany

来源：

NEUROLOGY | 2000年 / 55卷 / 11期

关键词：

D O I：

10.1212/WNL.55.11.1748

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To test the efficacy and safety of creatine (Cr) monohydrate in mitochondrial diseases, 16 patients with chronic progressive external ophthalmoplegia or mitochondrial myopathy were randomized in a crossover design to receive double-blind placebo or 20 g Cr/day for 4 weeks, Cr was well tolerated, but there were no significant effects with regard to exercise performance, eye movements, or activities of daily life, The power of this pilot study was limited and future multicenter trials are needed.

引用

页码：1748 / 1751

页数：4

共 12 条

[1] P-31 NMR-STUDY OF IMPROVEMENT IN OXIDATIVE-PHOSPHORYLATION BY VITAMIN-K3 AND VITAMIN-C IN A PATIENT WITH A DEFECT IN ELECTRON-TRANSPORT AT COMPLEX-III IN SKELETAL-MUSCLE [J].