Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome

被引:101
作者
Bajwa, Ednan K.
Yu, Chu-Ling
Gong, Michelle N.
Thompson, B. Taylor
Christiani, David C. [1 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Med,Pulm & Crit Care Unit, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Environm Hlth, Boston, MA 02115 USA
[3] Mt Sinai Sch Med, Dept Med, Div Pulm & Crit Care Med, New York, NY USA
关键词
acute respiratory distress syndrome; genetic predisposition to disease; genetic polymorphism;
D O I
10.1097/01.CCM.0000260243.22758.4F
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: Pre-B-cell colony-enhancing factor (PBEF) levels are elevated in bronchoalveolar lavage fluid and serum of patients with acute lung injury. There are several suspected functional polymorphisms of the corresponding PBEF gene. We hypothesized that variations in PBEF gene polymorphisms alter the risk of developing acute respiratory distress syndrome (ARDS). Design: Nested case-control study. Setting: Tertiary academic medical center. Patients: We studied 375 patents with ARDS and 787 at-risk controls genotyped for the PBEF T-1001G and C-1543T polymorphisms. Interventions: None. Measurements and Main Results: Patients with the -1001G (variant) allele had significantly greater odds of developing ARDS than wild-type homozygotes (odds ratio, 1.35; 95% confidence interval, 1.02-1.78). Patients with the -1543T (variant) allele did not have significantly different odds of developing ARDS than wild-type homozygotes (odds ratio, 0.86; 95% confidence interval, 0.65-1.13). When analysis was stratified by ARDS risk factor, -1543T was associated with decreased odds of developing ARDS in septic shock patients (odds ratio, 0.66; 95% confidence interval, 0.45-0.97). Also, -1001G was associated with increased hazard of intensive care unit mortality, whereas -1543T was associated with decreased hazard of 28-day and 60-day ARDS mortality, as well as shorter duration of mechanical ventilation. Similar results were found in analyses of the related GC (-1001G:-1543C) and TT (-1001T:-1543T) haplotypes. Conclusions: The PBEF T-1001G variant allele and related haplotype are associated with increased odds of developing ARDS and increased hazard of intensive care unit mortality among at-risk patients, whereas the C-1543T variant allele and related haplotype are associated with decreased odds of ARDS among patients with septic shock and better outcomes among patients with ARDS.
引用
收藏
页码:1290 / 1295
页数:6
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