New aspects of adipogenesis: Radicals and oxidative stress

被引：49

作者：

Gummersbach, Caroline ^{[1
,2
]}

Hemmrich, Karsten ^{[1
,2
]}

Kroencke, Klaus-Dietrich ^{[3
]}

Suschek, Christoph V. ^{[1
]}

Fehsel, Karin ^{[4
]}

Pallua, Norbert ^{[1
]}

机构：

[1] Univ Aachen, Rhein Westfal TH Aachen, Dept Plast Surg & Hand Surg, Burn Ctr,Univ Hosp, D-52074 Aachen, Germany

[2] Rhein Westfal TH Aachen, Univ Hosp, Interdisciplinary Ctr Clin Res BIOMAT, D-52057 Aachen, Germany

[3] Univ Dusseldorf, Inst Biochem & Mol Biol 1, D-40001 Dusseldorf, Germany

[4] Univ Dusseldorf, Dept Psychiat, Neurochem Res Unit, D-40001 Dusseldorf, Germany

来源：

DIFFERENTIATION | 2009年 / 77卷 / 02期

关键词：

Preadipocytes; Adipogenesis; Reactive oxygen species; Radicals; Nitric oxide; HUMAN ADIPOSE-TISSUE; NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; VISCERAL FAT ACCUMULATION; ACTIVATED RECEPTOR-GAMMA; FACTOR-I RECEPTOR; TRANSCRIPTIONAL REGULATION; INSULIN-RESISTANCE; ADIPOCYTE DIFFERENTIATION; ENDOTHELIAL-CELLS;

D O I：

10.1016/j.diff.2008.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Preadipocytes are multipotent a dipogenic precursor cells that can be isolated from mature adipose tissue. They have been receiving increasing attention in the context of obesity, type 2 diabetes, and other nutrition-associated diseases. Understanding the physiological and pathophysiological processes in fat neo-formation, energy homeostasis, and a dipose tissue physiology is the basis for research on metabolic diseases and the respective pharmaceutical intervention. While the hormonal influence on intracellular signaling in a dipogenesis has been intensively investigated, the effects of free radical formation and oxidative stress have just started to gain scientific attention. This review summarizes the present knowledge on the main molecular pathways in preadipocyte maturation and focuses on recent findings indicating that besides hormonal stimuli reactive oxygen species (ROS) and free radicals may also interact with preadipocyte differentiation. (C) 2008 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.

引用

页码：115 / 120

页数：6

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