Life and death decisions: Secondary complexes and lipid rafts in TNF receptor family signal transduction

被引：264

作者：

Muppidi, JR

Tschopp, J

Siegel, RM ^{[1
]}

机构：

[1] NIAMSD, Autoimmun Branch, Immunoregulat Unit, Bethesda, MD 20892 USA

[2] Univ Lausanne, Inst Biochem, BIL Biomed Res Ctr, CH-1066 Epalinges, Switzerland

[3] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA

来源：

IMMUNITY | 2004年 / 21卷 / 04期

关键词：

D O I：

10.1016/j.immuni.2004.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Signaling by receptors in the TNF receptor (TNFR) superfamily mediate biological outcomes ranging from inflammation to apoptosis and other forms of programmed cell death. How receptor signaling mediates these divergent responses is just beginning to be understood. Here, we discuss how receptor submembrane localization and the formation of alternate signaling complexes can alter the fate of cells stimulated through TNFRs with a death domain, also known as "death receptors."

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页码：461 / 465

页数：5

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