2-phenylspiroindenes: A novel class of Selective Estrogen Receptor Modulators (SERMs)

被引：36

作者：

Blizzard, TA ^{[1
]}

Morgan, JD ^{[1
]}

Mosley, RT ^{[1
]}

Birzin, ET ^{[1
]}

Frisch, K ^{[1
]}

Rohrer, SP ^{[1
]}

Hammond, ML ^{[1
]}

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)00985-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-phenylspiroindenes was prepared. The most active analogue (2) was found to be comparable in potency to raloxifene (1) as an estrogen receptor ligand. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：479 / 483

页数：5

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